Combined Micrococcal Nuclease and Exonuclease III Digestion Reveals Precise Positions of the Nucleosome Core/Linker Junctions: Implications for High-Resolution Nucleosome Mapping

Micrococcal nuclease (MNase) is extensively used in genome-wide mapping of nucleosomes but its preference for AT-rich DNA leads to errors in establishing precise positions of nucleosomes. Here, we show that the MNase digestion of nucleosomes assembled on a strong nucleosome positioning sequence, Wid...

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Detalles Bibliográficos
Publicado en:J Mol Biol
Autores principales: Nikitina, Tatiana, Wang, Difei, Gomberg, Misha, Grigoryev, Sergei A., Zhurkin, Victor B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7597529/
https://ncbi.nlm.nih.gov/pubmed/23458408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.02.026
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