Chromosomal instability upregulates interferon in acute myeloid leukemia

BACKGROUND: Chromosome instability (CIN) generates genetic and karyotypic diversity and is common in hematological malignancies. Low to moderate levels of CIN are well tolerated and can promote cancer proliferation; however, high levels of CIN are lethal. Thus, CIN may serve both as a prognostic fac...

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Pubblicato in:Genes Chromosomes Cancer
Autori principali: Jin, Ning, Lera, Robert F., Yan, Rachel E., Guo, Fen, Oxendine, Kim, Horner, Vanessa L., Hu, Yang, Wan, Jun, Mattison, Ryan J., Weaver, Beth A., Burkard, Mark E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7597364/
https://ncbi.nlm.nih.gov/pubmed/32557940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22880
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