Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference

Chromosomal instability (CIN)—persistent chromosome gain or loss through abnormal mitotic segregation—is a hallmark of cancer that drives aneuploidy. Intrinsic chromosome mis-segregation rate, a measure of CIN, can inform prognosis and is a promising biomarker for response to anti-microtubule agents...

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Detalhes bibliográficos
Main Authors: Andrew R Lynch, Nicholas L Arp, Amber S Zhou, Beth A Weaver, Mark E Burkard
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2022-04-01
Colecção:eLife
Assuntos:
aneuploidy
single-cell sequencing
agent-based modeling
mitosis
approximate Bayesian computation
Acesso em linha:https://elifesciences.org/articles/69799
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