8q24 clear cell renal cell carcinoma germline variant is associated with VHL mutation status and clinical aggressiveness

BACKGROUND: The four most commonly-mutated genes in clear cell renal cell carcinoma (ccRCC) tumors are BAP1, PBRM1, SETD2 and VHL. And, there are currently 14 known RCC germline variants that have been reproducibly shown to be associated with RCC risk. However, the association of germline genetics w...

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Библиографические подробности
Опубликовано в: :BMC Urol
Главные авторы: Eckel-Passow, Jeanette E., Yan, Huihuang, Kosel, Matthew L., Serie, Daniel, Decker, Paul A., Jenkins, Robert B., Costello, Brian, Leibovich, Bradley, Ho, Thai H., Parker, Alexander
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2020
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7597051/
https://ncbi.nlm.nih.gov/pubmed/33121461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12894-020-00745-9
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