Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial infarction, thrombocytopenia, and other end-organ damage. Animal models demonstrating end-organ protection in C3-defici...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Yu, Jia, Yuan, Xuan, Chen, Hang, Chaturvedi, Shruti, Braunstein, Evan M., Brodsky, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596849/
https://ncbi.nlm.nih.gov/pubmed/32877502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008248
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