Anti–platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe adverse effect of ChAdOx1 nCoV-19 COVID-19 vaccine (Vaxzevria) and Janssen Ad26.COV2.S COVID-19 vaccine, and it is associated with unusual thrombosis. VITT is caused by anti-platelet factor 4 (PF4) antibodies activating platelets...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Greinacher, Andreas, Selleng, Kathleen, Mayerle, Julia, Palankar, Raghavendra, Wesche, Jan, Reiche, Sven, Aebischer, Andrea, Warkentin, Theodore E., Muenchhoff, Maximilian, Hellmuth, Johannes C., Keppler, Oliver T., Duerschmied, Daniel, Lother, Achim, Rieg, Siegbert, Gawaz, Meinrad Paul, Mueller, Karin Anne Lydia, Scheer, Christian S., Napp, Matthias, Hahnenkamp, Klaus, Lucchese, Guglielmo, Vogelgesang, Antje, Flöel, Agnes, Lovreglio, Piero, Stufano, Angela, Marschalek, Rolf, Thiele, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294553/
https://ncbi.nlm.nih.gov/pubmed/34280256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2021012938
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