Anti–platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe adverse effect of ChAdOx1 nCoV-19 COVID-19 vaccine (Vaxzevria) and Janssen Ad26.COV2.S COVID-19 vaccine, and it is associated with unusual thrombosis. VITT is caused by anti-platelet factor 4 (PF4) antibodies activating platelets...

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Vydáno v:Blood
Hlavní autoři: Greinacher, Andreas, Selleng, Kathleen, Mayerle, Julia, Palankar, Raghavendra, Wesche, Jan, Reiche, Sven, Aebischer, Andrea, Warkentin, Theodore E., Muenchhoff, Maximilian, Hellmuth, Johannes C., Keppler, Oliver T., Duerschmied, Daniel, Lother, Achim, Rieg, Siegbert, Gawaz, Meinrad Paul, Mueller, Karin Anne Lydia, Scheer, Christian S., Napp, Matthias, Hahnenkamp, Klaus, Lucchese, Guglielmo, Vogelgesang, Antje, Flöel, Agnes, Lovreglio, Piero, Stufano, Angela, Marschalek, Rolf, Thiele, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2021
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294553/
https://ncbi.nlm.nih.gov/pubmed/34280256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2021012938
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