Germline mutations in the alternative pathway of complement predispose to HELLP syndrome

BACKGROUND. HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a severe variant of hypertensive disorders of pregnancy affecting approximately 1% of all pregnancies, and has significant maternal and fetal morbidity. Previously, we showed that upregulation of the alternative pat...

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Dettagli Bibliografici
Pubblicato in:JCI Insight
Autori principali: Vaught, Arthur J., Braunstein, Evan M., Jasem, Jagar, Yuan, Xuan, Makhlin, Igor, Eloundou, Solange, Baines, Andrea C., Merrill, Samuel A., Chaturvedi, Shruti, Blakemore, Karin, Sperati, C. John, Brodsky, Robert A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
Soggetti:
Clinical Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926944/
https://ncbi.nlm.nih.gov/pubmed/29563339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99128
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