Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance

Macrophage antibody (Ab)-dependent cellular phagocytosis (ADCP) is a major cytotoxic mechanism for both therapeutic unconjugated monoclonal Abs (mAbs) such as rituximab and Ab-induced hemolytic anemia and immune thrombocytopenia. Here, we studied the mechanisms controlling the rate and capacity of m...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Pinney, Jonathan J., Rivera-Escalera, Fátima, Chu, Charles C., Whitehead, Hannah E., VanDerMeid, Karl R., Nelson, Ashley M., Barbeau, Michelle C., Zent, Clive S., Elliott, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596847/
https://ncbi.nlm.nih.gov/pubmed/32556153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005571
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