C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice

Natural IgM antibodies (NAbs) have been shown to recognize injury-associated neoepitopes and to initiate pathogenic complement activation. The NAb termed C2 binds to a subset of phospholipids displayed on injured cells, and its role(s) in arthritis, as well as the potential therapeutic benefit of a...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Banda, Nirmal K., Tomlinson, Stephen, Scheinman, Robert I., Ho, Nhu, Ramirez, Joseline Ramos, Mehta, Gaurav, Wang, Guankui, Vu, Vivian Pham, Simberg, Dmitri, Kulik, Liudmila, Holers, V. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596757/
https://ncbi.nlm.nih.gov/pubmed/33178202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.575154
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