Multiple-Dose Pharmacokinetics of Ozanimod and its Major Active Metabolites and the Pharmacodynamic and Pharmacokinetic Interactions with Pseudoephedrine, a Sympathomimetic Agent, in Healthy Subjects

INTRODUCTION: The aims of this study were to characterize the multiple-dose pharmacokinetics (PK) of ozanimod’s major active metabolites (CC112273 and CC1084037) and to evaluate the pharmacodynamic and PK interactions with pseudoephedrine (PSE). METHODS: In this phase 1, single-center, randomized, d...

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Detalhes bibliográficos
Publicado no:Adv Ther
Main Authors: Tran, Jonathan Q., Zhang, Peijin, Walker, Susan, Ghosh, Atalanta, Syto, Mary, Wang, Xiaomin, Harris, Sarah, Palmisano, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Healthcare 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595987/
https://ncbi.nlm.nih.gov/pubmed/33025342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12325-020-01500-0
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