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Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms

Loss of Heterozygosity (LOH) typically refers to a phenomenon in which diploid cells that are heterozygous for a mutant allele lose their wild type allele through mutations. LOH is implicated in oncogenesis when it affects the remaining wild type copy of a tumor suppressor. Drosophila has been a use...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS Genet
Main Authors: Brown, Jeremy, Bush, Inle, Bozon, Justine, Su, Tin Tin
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595702/
https://ncbi.nlm.nih.gov/pubmed/33075096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009056
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