The function of peroxisome proliferator-activated receptors PPAR-γ and PPAR-δ in Mycobacterium leprae-induced foam cell formation in host macrophages

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). In lepromatous leprosy (LL), skin macrophages, harboring extensive bacterial multiplication, gain a distinctive foamy appearance due to increased intracellular lipid load. To determine the mechanism by which M. lepra...

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Bibliographic Details
Published in:PLoS Negl Trop Dis
Main Authors: Luo, Yuqian, Tanigawa, Kazunari, Kawashima, Akira, Ishido, Yuko, Ishii, Norihisa, Suzuki, Koichi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595635/
https://ncbi.nlm.nih.gov/pubmed/33075048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008850
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