Extensive trimming of short single-stranded DNA oligonucleotides during replication-coupled gene editing in mammalian cells

Through transfection of short single-stranded oligodeoxyribonucleotides (ssODNs) small genomic alterations can be introduced into mammalian cells with high precision. ssODNs integrate into the genome during DNA replication, but the resulting heteroduplex is prone to detection by DNA mismatch repair...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Genet
Egile Nagusiak: van Ravesteyn, Thomas W., Arranz Dols, Marcos, Pieters, Wietske, Dekker, Marleen, te Riele, Hein
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595315/
https://ncbi.nlm.nih.gov/pubmed/33119594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009041
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