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An allosteric interaction controls the activation mechanism of SHP2 tyrosine phosphatase
SHP2 is a protein tyrosine phosphatase (PTP) involved in multiple signaling pathways. Mutations of SHP2 can result in Noonan syndrome or pediatric malignancies. Inhibition of wild-type SHP2 represents a novel strategy against several cancers. SHP2 is activated by binding of a phosphopeptide to the N...
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| Publicado no: | Sci Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7595171/ https://ncbi.nlm.nih.gov/pubmed/33116231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75409-7 |
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