Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity

Endorepellin, the C-terminal domain of perlecan, is a powerful angiogenesis inhibitor. To dissect the mechanism of endorepellin-mediated endothelial silencing, we used an antibody array against multiple tyrosine kinase receptors. Endorepellin caused a widespread reduction in phosphorylation of key r...

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Hlavní autoři: Nyström, Alexander, Shaik, Zabeena P., Gullberg, Donald, Krieg, Thomas, Eckes, Beate, Zent, Roy, Pozzi, Ambra, Iozzo, Renato V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2009
Témata:
Vascular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786295/
https://ncbi.nlm.nih.gov/pubmed/19789387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-207134
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