Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities

In the current study, virtual screening of a small library of 1302 pyrrolizines bearing urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated for their cytotoxicity against three cancer (MCF-7, A2780, and HT29) and one normal (MRC-5) cell lines. The results of the...

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Dades bibliogràfiques
Publicat a:J Enzyme Inhib Med Chem
Autors principals: Shawky, Ahmed M., Ibrahim, Nashwa A., Abourehab, Mohammed A. S., Abdalla, Ashraf N., Gouda, Ahmed M.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594867/
https://ncbi.nlm.nih.gov/pubmed/33103497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1837124
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