Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent medulloblastoma and ependymoma

BACKGROUND: Recurrent pediatric medulloblastoma and ependymoma have a grim prognosis. We report a first-in-human, phase I study of intraventricular infusions of ex vivo expanded autologous natural killer (NK) cells in these tumors, with correlative studies. METHODS: Twelve patients were enrolled, 9...

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Опубликовано в: :Neuro Oncol
Главные авторы: Khatua, Soumen, Cooper, Laurence J N, Sandberg, David I, Ketonen, Leena, Johnson, Jason M, Rytting, Michael E, Liu, Diane D, Meador, Heather, Trikha, Prashant, Nakkula, Robin J, Behbehani, Gregory K, Ragoonanan, Dristhi, Gupta, Sumit, Kotrotsou, Aikaterini, Idris, Tagwa, Shpall, Elizabeth J, Rezvani, Katy, Colen, Rivka, Zaky, Wafik, Lee, Dean A, Gopalakrishnan, Vidya
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
Pediatric Neuro-Oncology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594549/
https://ncbi.nlm.nih.gov/pubmed/32152626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa047
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