Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent medulloblastoma and ependymoma

BACKGROUND: Recurrent pediatric medulloblastoma and ependymoma have a grim prognosis. We report a first-in-human, phase I study of intraventricular infusions of ex vivo expanded autologous natural killer (NK) cells in these tumors, with correlative studies. METHODS: Twelve patients were enrolled, 9...

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Udgivet i:Neuro Oncol
Main Authors: Khatua, Soumen, Cooper, Laurence J N, Sandberg, David I, Ketonen, Leena, Johnson, Jason M, Rytting, Michael E, Liu, Diane D, Meador, Heather, Trikha, Prashant, Nakkula, Robin J, Behbehani, Gregory K, Ragoonanan, Dristhi, Gupta, Sumit, Kotrotsou, Aikaterini, Idris, Tagwa, Shpall, Elizabeth J, Rezvani, Katy, Colen, Rivka, Zaky, Wafik, Lee, Dean A, Gopalakrishnan, Vidya
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Pediatric Neuro-Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594549/
https://ncbi.nlm.nih.gov/pubmed/32152626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa047
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