Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent medulloblastoma and ependymoma

BACKGROUND: Recurrent pediatric medulloblastoma and ependymoma have a grim prognosis. We report a first-in-human, phase I study of intraventricular infusions of ex vivo expanded autologous natural killer (NK) cells in these tumors, with correlative studies. METHODS: Twelve patients were enrolled, 9...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Khatua, Soumen, Cooper, Laurence J N, Sandberg, David I, Ketonen, Leena, Johnson, Jason M, Rytting, Michael E, Liu, Diane D, Meador, Heather, Trikha, Prashant, Nakkula, Robin J, Behbehani, Gregory K, Ragoonanan, Dristhi, Gupta, Sumit, Kotrotsou, Aikaterini, Idris, Tagwa, Shpall, Elizabeth J, Rezvani, Katy, Colen, Rivka, Zaky, Wafik, Lee, Dean A, Gopalakrishnan, Vidya
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Pediatric Neuro-Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594549/
https://ncbi.nlm.nih.gov/pubmed/32152626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa047
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