KRAS wild-type pancreatic ductal adenocarcinoma: molecular pathology and therapeutic opportunities

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, whose main molecular trait is the MAPK pathway activation due to KRAS mutation, which is present in 90% of cases. The genetic landscape of KRAS wild type PDAC can be divided into three categories. The first is represented by tumors with an...

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Bibliografske podrobnosti
izdano v:J Exp Clin Cancer Res
Main Authors: Luchini, Claudio, Paolino, Gaetano, Mattiolo, Paola, Piredda, Maria L., Cavaliere, Alessandro, Gaule, Marina, Melisi, Davide, Salvia, Roberto, Malleo, Giuseppe, Shin, Jae Il, Cargnin, Sarah, Terrazzino, Salvatore, Lawlor, Rita T., Milella, Michele, Scarpa, Aldo
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594413/
https://ncbi.nlm.nih.gov/pubmed/33115526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01732-6
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