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Targeting KRAS: The Elephant in the Room of Epithelial Cancers
Mutations of the proto-oncogene KRAS are the most frequent gain-of-function alterations found in cancer. KRAS is mutated in about 30% of all human tumors, but it could reach more than 90% in certain cancer types such as pancreatic adenocarcinoma. Although historically considered to be undruggable, a...
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| Publicado no: | Front Oncol |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7991835/ https://ncbi.nlm.nih.gov/pubmed/33777798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.638360 |
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