Acute myeloid leukemia–induced remodeling of the human bone marrow niche predicts clinical outcome

Murine models of myeloid neoplasia show how leukemia infiltration alters the hematopoietic stem cell (HSC) niche to reinforce malignancy at the expense of healthy hematopoiesis. However, little is known about the bone marrow architecture in humans and its impact on clinical outcome. Here, we dissect...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Chen, Yiyang, Hoffmeister, Lina Marie, Zaun, Yasmin, Arnold, Lucas, Schmid, Kurt Werner, Giebel, Bernd, Klein-Hitpass, Ludger, Hanenberg, Helmut, Squire, Anthony, Reinhardt, H. Christian, Dührsen, Ulrich, Bertram, Stefanie, Hanoun, Maher
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594397/
https://ncbi.nlm.nih.gov/pubmed/33108453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001808
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