Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions

TAR DNA-binding protein of 43 kDa (TDP-43) is a major component of intracellular aggregates formed in brains of the patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), which are correctively referred to as TDP-43 proteinopathies. A link between Ataxin-2 (A...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Watanabe, Ryohei, Higashi, Shinji, Nonaka, Takashi, Kawakami, Ito, Oshima, Kenichi, Niizato, Kazuhiro, Akiyama, Haruhiko, Yoshida, Mari, Hasegawa, Masato, Arai, Tetsuaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594343/
https://ncbi.nlm.nih.gov/pubmed/33115537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01055-9
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