Localized Interleukin-12 for Cancer Immunotherapy

Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable antitumor efficacy in preclinical models has yet to be replicated in humans. Early clinical trials in the mid-1990's sh...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Nguyen, Khue G., Vrabel, Maura R., Mantooth, Siena M., Hopkins, Jared J., Wagner, Ethan S., Gabaldon, Taylor A., Zaharoff, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593768/
https://ncbi.nlm.nih.gov/pubmed/33178203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.575597
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