Localized Interleukin-12 for Cancer Immunotherapy

Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable antitumor efficacy in preclinical models has yet to be replicated in humans. Early clinical trials in the mid-1990's sh...

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Autori principali: Khue G. Nguyen, Maura R. Vrabel, Siena M. Mantooth, Jared J. Hopkins, Ethan S. Wagner, Taylor A. Gabaldon, David A. Zaharoff
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020-10-01
Serie:Frontiers in Immunology
Soggetti:
interleukin-12 (IL-12)
cancer immunotherapy
cancer vaccine
cytokine delivery system
localized delivery
intratumoral administration
Accesso online:https://www.frontiersin.org/article/10.3389/fimmu.2020.575597/full
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