Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role

The lectin pathway (LP) of complement activation is believed to contribute to brain inflammation. The study aims to identify the key components of the LP contributing to TBI outcome as possible novel pharmacological targets. We compared the long-term neurological deficits and neuropathology of wild-...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Mercurio, D., Oggioni, M., Fumagalli, S., Lynch, N. J., Roscher, S., Minuta, D., Perego, C., Ippati, S., Wallis, R., Schwaeble, W. J., De Simoni, M.-G.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592565/
https://ncbi.nlm.nih.gov/pubmed/33115535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01041-1
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