Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer

BACKGROUND: Distant metastasis is the major cause of mortality in patients with locally advanced rectal cancer (LARC) following neoadjuvant chemoradiotherapy. Local radiotherapy can trigger an abscopal response to metastatic tumor cells. However, the abscopal effect is a rare event. CD4+ regulatory...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Ji, Dengbo, Song, Can, Li, Yongheng, Xia, Jinhong, Wu, Yanjing, Jia, Jinying, Cui, Xinxin, Yu, Songmao, Gu, Jin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2020
Schlagworte:
Basic Tumor Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592256/
https://ncbi.nlm.nih.gov/pubmed/33106387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000826
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