Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer

BACKGROUND: Distant metastasis is the major cause of mortality in patients with locally advanced rectal cancer (LARC) following neoadjuvant chemoradiotherapy. Local radiotherapy can trigger an abscopal response to metastatic tumor cells. However, the abscopal effect is a rare event. CD4+ regulatory...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Ji, Dengbo, Song, Can, Li, Yongheng, Xia, Jinhong, Wu, Yanjing, Jia, Jinying, Cui, Xinxin, Yu, Songmao, Gu, Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2020
Témata:
Basic Tumor Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592256/
https://ncbi.nlm.nih.gov/pubmed/33106387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000826
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