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Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo
De novo DNA methylation (DNAme) during mammalian spermatogenesis yields a densely methylated genome, with the exception of CpG islands (CGIs), which are hypomethylated in sperm. While the paternal genome undergoes widespread DNAme loss before the first S-phase following fertilization, recent mass sp...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7591512/ https://ncbi.nlm.nih.gov/pubmed/33110091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19279-7 |
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