Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo

De novo DNA methylation (DNAme) during mammalian spermatogenesis yields a densely methylated genome, with the exception of CpG islands (CGIs), which are hypomethylated in sperm. While the paternal genome undergoes widespread DNAme loss before the first S-phase following fertilization, recent mass sp...

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Vydáno v:Nat Commun
Hlavní autoři: Richard Albert, Julien, Au Yeung, Wan Kin, Toriyama, Keisuke, Kobayashi, Hisato, Hirasawa, Ryutaro, Brind’Amour, Julie, Bogutz, Aaron, Sasaki, Hiroyuki, Lorincz, Matthew
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591512/
https://ncbi.nlm.nih.gov/pubmed/33110091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19279-7
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