Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells

Transcription of endogenous retroviruses (ERVs) is inhibited by de novo DNA methylation during gametogenesis, a process initiated after birth in oocytes and at approximately embryonic day 15.5 (E15.5) in prospermatogonia. Earlier in germline development, the genome, including most retrotransposons,...

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Detalhes bibliográficos
Main Authors: Liu, Sheng, Brind’Amour, Julie, Karimi, Mohammad M., Shirane, Kenjiro, Bogutz, Aaron, Lefebvre, Louis, Sasaki, Hiroyuki, Shinkai, Yoichi, Lorincz, Matthew C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4173156/
https://ncbi.nlm.nih.gov/pubmed/25228647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.244848.114
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