Characterization of AAV-Specific Affinity Ligands: Consequences for Vector Purification and Development Strategies

Affinity-based purification of adeno-associated virus (AAV) vectors has replaced density-based methods for vectors used in clinical settings. This method utilizes camelid single-domain antibodies recognizing AAV capsids. These include AVB Sepharose (AVB) and POROS CaptureSelect affinity ligand for A...

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Publicat a:Mol Ther Methods Clin Dev
Autors principals: Mietzsch, Mario, Smith, J. Kennon, Yu, Jennifer C., Banala, Vibhu, Emmanuel, Shanan N., Jose, Ariana, Chipman, Paul, Bhattacharya, Nilakshee, McKenna, Robert, Agbandje-McKenna, Mavis
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591348/
https://ncbi.nlm.nih.gov/pubmed/33145372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.10.001
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