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A mathematical model of the metastatic bottleneck predicts patient outcome and response to cancer treatment

Metastases are the main reason for cancer-related deaths. Initiation of metastases, where newly seeded tumor cells expand into colonies, presents a tremendous bottleneck to metastasis formation. Despite its importance, a quantitative description of metastasis initiation and its clinical implications...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Szczurek, Ewa, Krüger, Tyll, Klink, Barbara, Beerenwinkel, Niko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591057/
https://ncbi.nlm.nih.gov/pubmed/33006977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008056
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