Serum indoxyl sulfate concentrations associate with progression of chronic kidney disease in children

The uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (pCS) accumulate in patients with chronic kidney disease (CKD) as a consequence of altered gut microbiota metabolism and a decline in renal excretion. Despite of solid experimental evidence for nephrotoxic effects, the impact of uremic toxi...

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Publicado en:PLoS One
Autores principales: Holle, Johannes, Kirchner, Marietta, Okun, Jürgen, Bayazit, Aysun K., Obrycki, Lukasz, Canpolat, Nur, Bulut, Ipek Kaplan, Azukaitis, Karolis, Duzova, Ali, Ranchin, Bruno, Shroff, Rukshana, Candan, Cengiz, Oh, Jun, Klaus, Günter, Lugani, Francesca, Gimpel, Charlotte, Büscher, Rainer, Yilmaz, Alev, Baskin, Esra, Erdogan, Hakan, Zaloszyc, Ariane, Özcelik, Gül, Drozdz, Dorota, Jankauskiene, Augustina, Nobili, Francois, Melk, Anette, Querfeld, Uwe, Schaefer, Franz
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591021/
https://ncbi.nlm.nih.gov/pubmed/33108385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0240446
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