Serum indoxyl sulfate concentrations associate with progression of chronic kidney disease in children

The uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (pCS) accumulate in patients with chronic kidney disease (CKD) as a consequence of altered gut microbiota metabolism and a decline in renal excretion. Despite of solid experimental evidence for nephrotoxic effects, the impact of uremic toxi...

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Veröffentlicht in:PLoS One
Hauptverfasser: Holle, Johannes, Kirchner, Marietta, Okun, Jürgen, Bayazit, Aysun K., Obrycki, Lukasz, Canpolat, Nur, Bulut, Ipek Kaplan, Azukaitis, Karolis, Duzova, Ali, Ranchin, Bruno, Shroff, Rukshana, Candan, Cengiz, Oh, Jun, Klaus, Günter, Lugani, Francesca, Gimpel, Charlotte, Büscher, Rainer, Yilmaz, Alev, Baskin, Esra, Erdogan, Hakan, Zaloszyc, Ariane, Özcelik, Gül, Drozdz, Dorota, Jankauskiene, Augustina, Nobili, Francois, Melk, Anette, Querfeld, Uwe, Schaefer, Franz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591021/
https://ncbi.nlm.nih.gov/pubmed/33108385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0240446
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