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Nucleotide Excision Repair, XPA-1, and Translesion Synthesis Complex, POLZ-1 and REV-1, are Critical for Interstrand Crosslink Repair in C. elegans Germ Cells

Interstrand crosslinks (ICLs) are adducts of covalently linked nucleotides in opposing DNA strands that obstruct replication and prime cells for malignant transformation or premature cell death. ICLs may be caused by alkylating agents or ultraviolet (UV) irradiation. These toxic lesions are removed...

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Библиографические подробности
Опубликовано в: :Biochemistry
Главные авторы: Oh, Sinae, Bae, Woori, Alfhili, Mohammad A., Lee, Myon Hee
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7590238/
https://ncbi.nlm.nih.gov/pubmed/32945661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00719
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