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Nucleotide Excision Repair, XPA-1, and Translesion Synthesis Complex, POLZ-1 and REV-1, are Critical for Interstrand Crosslink Repair in C. elegans Germ Cells
Interstrand crosslinks (ICLs) are adducts of covalently linked nucleotides in opposing DNA strands that obstruct replication and prime cells for malignant transformation or premature cell death. ICLs may be caused by alkylating agents or ultraviolet (UV) irradiation. These toxic lesions are removed...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7590238/ https://ncbi.nlm.nih.gov/pubmed/32945661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00719 |
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