Mifepristone Decreases Chronic Voluntary Ethanol Consumption in Rhesus Macaques

The efficacy of short-term treatment with mifepristone (MIFE), a high-affinity, nonselective glucocorticoid receptor antagonist, to reduce ethanol drinking was tested in a rhesus macaque model. Stable individual daily ethanol intakes were established, ranging from 1.6 to 4.0 g/kg per day (n = 9 monk...

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Pubblicato in:J Pharmacol Exp Ther
Autori principali: Jimenez, Vanessa A., Walter, Nicole A.R., Shnitko, Tatiana A., Newman, Natali, Diem, Kaya, Vanderhooft, Lauren, Hunt, Hazel, Grant, Kathleen A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2020
Soggetti:
Behavioral Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7590013/
https://ncbi.nlm.nih.gov/pubmed/32873623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000169
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