Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells

Iron is crucial to satisfy several mitochondrial functions including energy metabolism and oxidative phosphorylation. Patients affected by Myelodysplastic Syndromes (MDS) and acute myeloid leukemia (AML) are frequently characterized by iron overload (IOL), due to continuous red blood cell (RBC) tran...

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Pubblicato in:Int J Mol Sci
Autori principali: Calabrese, Chiara, Panuzzo, Cristina, Stanga, Serena, Andreani, Giacomo, Ravera, Silvia, Maglione, Alessandro, Pironi, Lucrezia, Petiti, Jessica, Shahzad Ali, Muhammad, Scaravaglio, Patrizia, Napoli, Francesca, Fava, Carmen, De Gobbi, Marco, Frassoni, Francesco, Saglio, Giuseppe, Bracco, Enrico, Pergolizzi, Barbara, Cilloni, Daniela
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589297/
https://ncbi.nlm.nih.gov/pubmed/33081324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207674
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