Repeated dermal application of the common preservative methylisothiazolinone triggers local inflammation, T cell influx, and prolonged mast cell-dependent tactile sensitivity in mice

Occupational exposure to toxic chemicals increases the risk of developing localized provoked vulvodynia—a prevalent, yet poorly understood, chronic condition characterized by sensitivity to touch and pressure, and accumulation of mast cells in painful tissues. Here, we topically sensitized female ND...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kline, Jaclyn M., Arriaga-Gomez, Erica, Yangdon, Tenzin, Boo, Beebie, Landry, Jasmine, Saldías-Montivero, Marietta, Neamonitaki, Nefeli, Mengistu, Hanna, Silverio, Sayira, Zacheis, Hayley, Pasha, Dogukan, Martinov, Tijana, Fife, Brian T., Chatterjea, Devavani
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588120/
https://ncbi.nlm.nih.gov/pubmed/33104726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0241218
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