Specific ablation of the NCoR corepressor δ splice variant reveals alternative RNA splicing as a key regulator of hepatic metabolism

The NCoR corepressor plays critical roles in mediating transcriptional repression by both nuclear receptors and non-receptor transcription factors. Alternative mRNA splicing of NCoR produces a series of variants with differing molecular and biological properties. The NCoRω splice-variant inhibits ad...

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Bibliographic Details
Published in:PLoS One
Main Authors: Goodson, Michael L., Knotts, Trina A., Campbell, Elsie L., Snyder, Chelsea A., Young, Briana M., Privalsky, Martin L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588069/
https://ncbi.nlm.nih.gov/pubmed/33104749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0241238
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