Relaxed peripheral tolerance drives broad de novo autoreactivity in severe COVID-19

An emerging feature of COVID-19 is the identification of autoreactivity in patients with severe disease that may contribute to disease pathology, however the origin and resolution of these responses remain unclear. Previously, we identified strong extrafollicular B cell activation as a shared immune...

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Detalhes bibliográficos
Publicado no:medRxiv
Main Authors: Woodruff, Matthew C., Ramonell, Richard P., Saini, Ankur Singh, Haddad, Natalie S., Anam, Fabliha A., Rudolph, Mark E., Bugrovsky, Regina, Hom, Jennifer, Cashman, Kevin S., Nguyen, Doan C., Kyu, Shuya, Piazza, Michael, Tipton, Christopher M., Jenks, Scott A., Lee, F. Eun-Hyung, Sanz, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7587839/
https://ncbi.nlm.nih.gov/pubmed/33106819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.21.20216192
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