Dominant extrafollicular B cell responses in severe COVID-19 disease correlate with robust viral-specific antibody production but poor clinical outcomes

A wide clinical spectrum has become a hallmark of the SARS-CoV-2 (COVID-19) pandemic, although its immunologic underpinnings remain to be defined. We have performed deep characterization of B cell responses through high-dimensional flow cytometry to reveal substantial heterogeneity in both effector...

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Pubblicato in:medRxiv
Autori principali: Woodruff, Matthew, Ramonell, Richard, Cashman, Kevin, Nguyen, Doan, Saini, Ankur, Haddad, Natalie, Ley, Ariel, Kyu, Shuya, Howell, J. Christina, Ozturk, Tugba, Lee, Saeyun, Chen, Weirong, Estrada, Jacob, Morrison-Porter, Andrea, Derrico, Andrew, Anam, Fabliha, Sharma, Monika, Wu, Henry, Le, Sang, Jenks, Scott, Tipton, Christopher M, Hu, Wiliam, Lee, F. Eun-Hyung, Sanz, Ignacio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276991/
https://ncbi.nlm.nih.gov/pubmed/32511635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.04.29.20083717
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