Diversity, cellular origin and autoreactivity of antibody-secreting cell expansions in acute Systemic Lupus Erythematosus

Acute SLE courses with antibody-secreting cells (ASC) surges whose origin, diversity, and contribution to serum autoantibodies remain unknown. Deep sequencing, autoantibody proteome and single-cell analysis demonstrated highly diversified ASC punctuated by V(H)4-34 clones that produce dominant serum...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Tipton, Christopher M, Fucile, Christopher F, Darce, Jaime, Chida, Asiya, Ichikawa, Travis, Gregoretti, Ivan, Schieferl, Sandra, Hom, Jennifer, Jenks, Scott, Feldman, Ron J, Mehr, Ramit, Wei, Chungwen, Lee, F. Eun-Hyung, Cheung, Wan Cheung, Rosenberg, Alexander F, Sanz, Iñaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512288/
https://ncbi.nlm.nih.gov/pubmed/26006014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3175
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