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Viral surface geometry shapes influenza and coronavirus spike evolution through antibody pressure

The evolution of circulating viruses is shaped by their need to evade antibody response, which mainly targets the glycoprotein (spike). However, not all antigenic sites are targeted equally by antibodies, leading to complex immunodominance patterns. We used 3D computational models to estimate antibo...

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Bibliografski detalji
Izdano u:bioRxiv
Glavni autor: Amitai, Assaf
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7587782/
https://ncbi.nlm.nih.gov/pubmed/33106808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.20.347641
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