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Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution
The functional HIV-1 envelope glycoprotein (Env) trimer, the target of anti-HIV-1 neutralizing antibodies (Abs), is innately labile and coexists with non-native forms of Env. This lability and heterogeneity in Env has been associated with its tendency to elicit non-neutralizing Abs. Here, we use dir...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3585149/ https://ncbi.nlm.nih.gov/pubmed/23468626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003184 |
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