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Immune-Mediated Loss of Transgene Expression in Skin: Implications for Cutaneous Gene Therapy

A clearer understanding of the immune-mediated loss of transgene from cutaneous epithelium is necessary for development of effective clinical gene therapy protocols for patients who carry null mutations in the target gene. We have used retrovirus-mediated transfer of lacZ to mouse skin as a model to...

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發表在:Mol Ther
Main Authors: Ghazizadeh, Soosan, Kalish, Richard S., Taichman, Lorne B.
格式: Artigo
語言:Inglês
出版: 2003
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7587125/
https://ncbi.nlm.nih.gov/pubmed/12668125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/s1525-0016(03)00013-3
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