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Immune-Mediated Loss of Transgene Expression in Skin: Implications for Cutaneous Gene Therapy

A clearer understanding of the immune-mediated loss of transgene from cutaneous epithelium is necessary for development of effective clinical gene therapy protocols for patients who carry null mutations in the target gene. We have used retrovirus-mediated transfer of lacZ to mouse skin as a model to...

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Foilsithe in:Mol Ther
Main Authors: Ghazizadeh, Soosan, Kalish, Richard S., Taichman, Lorne B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2003
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7587125/
https://ncbi.nlm.nih.gov/pubmed/12668125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/s1525-0016(03)00013-3
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