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Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates

[Image: see text] The generation of highly unstable chloromethylmagnesium chloride in a continuous flow reactor and its reaction with aldehydes and ketones is reported. With this strategy, chlorohydrins and epoxides were synthesized within a total residence time of only 2.6 s. The outcome of the rea...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: von Keutz, Timo, Cantillo, David, Kappe, C. Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586391/
https://ncbi.nlm.nih.gov/pubmed/32914630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c02725
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