Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate

[Image: see text] The cytochromes P450 are heme-dependent enzymes that catalyze many vital reaction processes in the human body related to biodegradation and biosynthesis. They typically act as mono-oxygenases; however, the recently discovered P450 subfamily TxtE utilizes O(2) and NO to nitrate arom...

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Pubblicato in:J Am Chem Soc
Autori principali: Louka, Savvas, Barry, Sarah M., Heyes, Derren J., Mubarak, M. Qadri E., Ali, Hafiz Saqib, Alkhalaf, Lona M., Munro, Andrew W., Scrutton, Nigel S., Challis, Gregory L., de Visser, Sam P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586343/
https://ncbi.nlm.nih.gov/pubmed/32811149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c05070
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